斯坦福大学肝脏研究方向招收博士、博士后、访问学者
该项目主要研究嵌合小鼠肝脏组织，并对嵌合体小鼠检测肝毒性，旨在开发人类肝脏替代品。申请者需要具备医学博士、生物学或相关专业博士学位，并且拥有药理学和小鼠模型研究经验。最好拥有iPS细胞生成研究经验。有强大的论文发表记录。截止日期为2014年10月7日。
Location Stanford, CA, United States
Posted August 07, 2014
Expires October 07, 2014
Job type Postdoctoral
We have received a 5-year Transformative RO1 award from the NIDDK to use chimeric mice with fully mature and functional human liver tissue to accomplish two goals. (i) Demonstrate that human pharmacogenetic analyses can be performed in these mice. We have recently shown that chimeric mice can be detect liver toxicities that would be missed with conventional rodent models. (ii) Develop methods that enable autologous human liver replacement. This could enable a complete paradigm-shift where ‘liver transplantation’ is performed using autologous adipocyte-derived stem cells without immunosuppression. We have demonstrated that iPS cells can also reconstitute human liver, and we have begun modeling human genetic liver diseases in these mice. We have established an off-site barrier facility that is solely dedicated to breeding and experimentation on these mice. State of the art methods for ultra-sound guided cell transplantation into mice, stem cell differentiation are utilized.
Applicant Requirements:
M.D. and/or Ph.D. in a biologically relevant area and experience with the
following:
1) In vivo characterization of mouse models and/or pharmacology modeling
2) A publication record demonstrating productive use of in vivo modeling, a strong interest in biomedical research, and a demonstrated ability to deal with complex biological problems.
3) Experience with stem or iPS cell generation and experimentation is desired.
斯坦福大学(Stanford University)全称为小利兰·斯坦福大学(Leland Stanford Junior University)，是美国的一所私立大学，被公认为世界上最杰出的大学之一。斯坦福大学于1891年由利兰·斯坦福建立，位于加利福尼亚州的斯坦福市，临近旧金山。斯坦福大学拥有的资产属于世界大学中最大的之一，它占地35平方公里，是美国面积第二大的大学。
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